San Francisco 49ers vs Arizona Cardinals
Sunday, September 27, 2026 · 20:05 UTC
San Francisco 49ers host Arizona Cardinals in the NFL on Sunday, September 27, 2026, starting at 20:05 UTC. Here is how the two teams stack up — the head-to-head history, current form and the latest bookmaker odds — ahead of the BetEX AI verdict on this game.
Head-to-head record
These two sides have met 10 times in our head-to-head records, with 5 wins for San Francisco 49ers against 5 for Arizona Cardinals. Historically this fixture could hardly be more even. Meetings between the two average 49.3 points per game. Their most recent meetings on record: Arizona Cardinals 47-24 San Francisco 49ers (2025-01-05); San Francisco 49ers 23-24 Arizona Cardinals (2024-10-06); Arizona Cardinals 29-45 San Francisco 49ers (2023-12-17).
| Date | Home | Score | Away |
|---|---|---|---|
| 2025-01-05 | Arizona Cardinals | 47-24 | San Francisco 49ers |
| 2024-10-06 | San Francisco 49ers | 23-24 | Arizona Cardinals |
| 2023-12-17 | Arizona Cardinals | 29-45 | San Francisco 49ers |
| 2023-10-01 | San Francisco 49ers | 35-16 | Arizona Cardinals |
| 2023-01-08 | San Francisco 49ers | 38-13 | Arizona Cardinals |
Recent form
San Francisco 49ers come into this one having won 4 and lost 1 of their last 5 (L-W-W-W-W). Over that run they have scored 119 points and conceded 141. That works out to a 80% form rating over the period.
Arizona Cardinals come into this one having won 2 and lost 3 of their last 5 (L-W-L-L-W). Over that run they have scored 134 points and conceded 120. That works out to a 40% form rating over the period.
🤖 The BetEX AI verdict on San Francisco 49ers vs Arizona Cardinals
Members see what our model ensemble makes of this game:
- AI pick & win probabilities for every outcome
- Model confidence score
- Key factors behind the call
- Value-bet detection against the market odds
How BetEX AI analyses this fixture
BetEX AI runs every fixture on this page through an ensemble of statistical models — Elo-style team ratings, scoring-rate (lambda) models and head-to-head history — refreshed daily from live competition data. The ensemble produces a win probability for each outcome, a confidence score, and flags games where the model's probability disagrees with the bookmaker line by enough to matter. Those outputs are reserved for members; everything above comes from the same underlying match data.
Predictions and statistics are for informational purposes only and are no guarantee of results. Please bet responsibly — never wager more than you can afford to lose. 18+ only.